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pentobarbital will lessen the extent or influence of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Powerful or average CYP3A4 inducers appreciably lessen guanfacine plasma concentrations and elimination half-existence.pentobarbital will lessen the level or effect of buprenorphine by in